In terms of removing negatives, there are only a few I really bother with - such as Kleptomania, Curious, and Antsy (which causes idle heroes to generate stress at the Hamlet). Outside of that, you rarely - if ever - need three cells available at one time. That's pretty much the only reason I level up the Sanitarium at all, because having 3 cells + free week = three heroes with a locked positive + removed negative at no gold cost. In terms of locking quirks, I never honestly bother unless (a) I'm stinking rich and/or into the end-game, or (b) when you activate the sanitarium-related town event to make quirk management free for a week. It's best to think of it like added specialization. Use Indiscriminate Science in conjunction with another Hero to provide heals when your party has high health.The best combat stats across the board are speed and accuracy, so it's never a bad idea to maintain quirks that are related to those - at least when it comes to specific heroes. Battlefield Medicine can be used as your primary healing ability, but you only have three charges, takes a couple of turns on cooldown, and requires 33% or lower health. Noxious Blast and Plague Grenade can be used as your primary Blight damage moves. Trinkets: Annotated Textbook, Storage Room Key, Protectorate, Pulsing Heart.Skills: Noxious Blast, Battlefield Medicine, Ounce of Prevention, Plague Grenade, Indiscriminate Science.The Healing Plague Doctor build is probably how most players will use them, making it the most effective build. The two best builds for The Plague Doctor include: The Plague Doctor is one of the better healers in the game but can be used as a support heals with DPS capabilities with her Blight skills. Darkest Dungeon 2 The Plague Doctor Builds
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